Ipamorelin dosage — what was administered, to what, and how.

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This page reports the ipamorelin doses used in published studies. It is a record of what researchers gave to cells, rats, ferrets, and a small number of human volunteers — not a guide for anyone to follow. There is no approved human dose, because there is no approved human use ^[3].

Doses are written the way the studies wrote them: a number, a species, and a route (how it went in — into a vein, under the skin, into the belly cavity). 'IV' means intravenous, 'SC' subcutaneous, 'IP' intraperitoneal. Where the only data is in animals, it says so. Where community 'stack' protocols exist, they are described as anecdotal and unverified, with no peer-reviewed human basis — and no number is offered as a recommendation. Nothing on this page tells you to take anything.

Doses used in human studies

Two human studies define the entire dosed human record, both intravenous.

The 1999 PK/PD study gave single IV infusions over 15 minutes at 4.21, 14.02, 42.13, 84.27, and 140.45 nmol/kg in healthy male volunteers (n=8 per level). Kinetics were dose-proportional across that range ^[2].

The 2014 Phase 2 ileus trial gave 0.03 mg/kg IV twice daily, on postoperative days 1 through 7 or until discharge, in 114 bowel-resection patients ^[3]. Both used the intravenous route under clinical supervision. Neither establishes a self-administration protocol, and the trial did not demonstrate efficacy ^[3].

Doses used in animal studies

Animal doses span routes and models.

Rat bone-growth study: 18, 90, and 450 microg/day subcutaneously, divided three times daily, for 15 days ^[4]. A separate rat bone-mineral study used 0.5 mg/kg/day continuous SC by osmotic minipump over 12 weeks. A rat postoperative-ileus model used 0.1-1 mg/kg IV, repeated four times daily.

Ferret cachexia study (2024): 1-3 mg/kg intraperitoneally ^[5]. These are research doses in research species. They do not scale to a human dose, and this site does not attempt the conversion.

Routes that have been studied

Ipamorelin has been studied by several routes. Intravenous dominates the human PK and clinical work and much rodent efficacy testing. Subcutaneous appears in the rodent bone and body-composition studies and is the dominant route in community use. Intranasal has rodent PK with roughly 20% bioavailability. Intraperitoneal appears in rodent and ferret efficacy work.

Oral does not work for ipamorelin itself — it is not orally bioavailable. Only engineered ipamorelin-derived analogs achieve oral activity (NN703 reached about 30% in dogs) ^[7]. That distinction matters: oral 'ipamorelin' claims describe analogs, not the parent peptide.

How much cjc-1295 ipamorelin should i take

How much cjc-1295 ipamorelin should i take: this site cannot and does not answer that, because no peer-reviewed human dosing exists for the combination. Community 'stack' protocols that pair ipamorelin with CJC-1295 use subcutaneous regimens with no controlled-trial basis — they are anecdotal, not recommended, and not endorsed here ^[3]. The only human ipamorelin dosing in the literature is the IV research dosing above, none of it self-administered. No combination dose is provided.

How to reconstitute cjc-1295 ipamorelin 5mg

How to reconstitute cjc-1295 ipamorelin 5mg: as a general research-handling matter, lyophilized (freeze-dried) peptide is reconstituted with bacteriostatic water for laboratory handling. As a peptide, ipamorelin degrades with heat and repeated freeze-thaw, so reconstituted solution is typically kept refrigerated. These are general handling observations drawn from the research-supply literature — not a clinical preparation instruction, not a dose, and not guidance for human use. This site does not provide a reconstitution protocol for self-administration.

Half-life and timing

Terminal half-life in healthy human volunteers is about 2 hours (IV), with clearance 0.078 L/h/kg and steady-state volume of distribution 0.22 L/kg ^[2]. The GH response is a single discrete pulse peaking near 40 minutes after dosing ^[2]. In rats, plasma clearance runs roughly 5-fold lower than GHRP-6. The detailed read on clearance and how long it lingers is on the how long does ipamorelin stay in your system page.